Similarly, a decrease in the cross-sectional area of fat cells was observed. Department of Pharmacology, K. Abstract The present study was undertaken to explore the effect of piperine in obesity-induced dyslipidemia. Experiment 2: Piper nigrum commonly known as black pepper and Piper longum commonly known as long pepper are highly reputed plants in the ayurvedic system of medicine.
Fat-pad Analysis At the end of the eleventh week, animals were decapitated between The statistical analysis for determining the significant difference was performed using the student's paired t-test and the Tucky one way ANOVA test test.
The functional ingredients and the mechanism of action of RMR should be determined in future studies. Body weight and liver lipids of rats fed with a standard diet or high-fat diet, either with or without proanthocyanidin treatment Full size table HFD also significantly increased liver mass, hepatic lipids, TG and TC levels Table 1.
Diet is closely related to the development of obesity; however, certain food components have been reported to exhibit antiobese activity. These results indicate that the benefit of RMR might be due to its content of monacolin K and other ingredients.
In normolipidemic rats GSPE was administered acutely whereas in the present experiment it was administered chronically.
TFG seeds have been shown to possess hypoglycemic, hypolipidemic, and antioxidant effects [ 7 ]. The 0.
SHP is a nuclear receptor that acts as an inducible repressor of other nuclear receptors and transcription factors. Thus, we used reverse transcription—PCR to analyze the differential expression of key genes controlling TG and cholesterol metabolism in the liver Table 3 and gain further insight into how GSPE improves the plasma lipid profile.
Differentiated adipocytes incorporate glucose and free fatty acids to synthesize and accumulate TG as energy. The diminished activity of MC-4 receptors not only increases the adiposity, but also increases the risk of its associated metabolic syndromes.
At the cellular level, enlargement of the adipose tissue mass has been characterized by an increase in the size hypertrophy or number hyperplasia of adipocytes. As plant proteins, dietary fiber and polyphenols do possess health benefits in metabolic disorders; therefore, in the present study, the inhibitory effect fenugreek extract was evaluated on fat accumulation and dyslipidemia in high fat diet-induced obese rats.
To verify whether monacolin K inhibited adipogenesis, we cultured cells in the presence or absence of lovastatin at the indicated concentrations and examined the intracellular TG content. The doses of RMR used in this study were calculated according to Boyd's formula for body surface area, 31 such that a daily dose of 0.
Table 2: Melanocortin activity may also be increased by an endogenous inhibition of inverse agonists agouti-related peptide of melanocortin receptors. Given that plasma TG levels heavily depend on extrahepatic uptake, we quantified lipoprotein lipase LPL and CPT1 expression in adipose tissue and muscle results not shown.
No significant differences in cell numbers in either type of adipose tissue were noted between the diet groups. Flavonoid contents of the extract were determined as follows: Three weeks later, the rats were randomly assigned to one of the following diets for 6 weeks: This presumption should be tested in future experiments.
Obesity leads to the development of insulin resistance, type-2 diabetes, coronary heart disease, cancer, respiratory disease, and osteoarthritis [ 2 ]. Fenugreek galactomannan form a viscous gel in the intestine and inhibit glucose and lipid absorption [ 12 ].
Molecular weight of different bands was calibrated with the standard proteins markers: In the animal study, 0.Objective. We previously found that lipoic acid (LA) improved high-fat diet (HFD)–induced dyslipidemia in rats.
To elucidate the molecular mechanisms of that effect, we carried out experiments aimed at analyzing biochemical parameters and gene expression justgohostelbraga.com by: Galactooligosaccharides (GOS) or fucoidan extracted from Undaria pinnatifida ameliorate high-fat diet induced dyslipidemia, hepatic tissue steatosis and aortic arch injury in SD rats.
GOS significantly increased Verrucomicrobia, Bacteroidetes, Blautia, and Akkermansia, but decreased Firmicutes, and FUC significantly decreased Aerococcus and justgohostelbraga.com: Qichao Chen, Min Liu, Pengyu Zhang, Shujun Fan, Jinli Huang, Shunying Yu, Caihua Zhang, Huajun Li.
Nov 03, · In this study, we examined the role of miR in the cardiac and metabolic alterations promoted by high fat (HF) diet. We found that loss of miR attenuated the gain of fat mass and prevented dyslipidemia induced by HF diet, although the body weight gain, or glucose intolerance and insulin resistance did not seem to be justgohostelbraga.com by: 3.
nutrients Article Aged Oolong Tea Reduces High-Fat Diet-Induced Fat Accumulation and Dyslipidemia by Regulating the AMPK/ACC Signaling Pathway Erdong Yuan 1 ID, Xuefei Duan 1, Limin Xiang 2, Jiaoyan Ren 1,3, Xingfei Lai 2, Qiuhua Li 2, Lingli Sun 2,* and Shili Sun 2,* 1 School of Food Science and Engineering, South China University of Technology, GuangzhouChina;Cited by: 6.
Jul 07, · GSPE treatment prevents dyslipidemia induced by high-fat diet. The body weight of rats fed with an HFD was significantly higher (approximately 40%) than those in the control group ().After 13 Cited by: Apr 29, · The correlation found between dyslipidemia and oxidative stress in this study shows that dyslipidemia induced by ingestion of high fat diet is the primary cause of lipid peroxidation.
Therefore, the possible reason for improvement in dyslipidemia with AqE-TFG may be due to reduction in oxidative stress in HFD fed rats.